Control of inflammatory cytokines and clinical efficacy analysis of disposable VSD negative pressure drainage technique in skin defects, bone defects and traumatic infections of extremities
一次性VSD负压引流技术在四肢皮肤缺损、骨缺损及创面感染对炎症细胞因子的控制及临床疗效分析

摘要

目的 观察四肢皮肤缺损、骨缺损及感染患者使用一次性负压引流技术（Vacuum Sealing Draina VSD）治疗对炎症细胞因子控制及临床的疗效分析。方法 将2021年1月-2021年10月收治的10例四肢皮肤缺损、骨缺损及感染创面患者，随机分组分为治疗组与对照组，每组各5例，分别采用一次性VSD负压引流技术治疗、常规换药治疗后再次手术治疗的对比效果。结果 5例接受一次性VSD负压引流技术治疗炎症细胞因子控制时间需5.0±2.3天，创面愈合需18±2.5天，功能康复需28±5.5天；5例接受常规换药治疗炎症细胞因子控制时间需14.1±3.0天，创面愈合需35±4.2天，功能康复需53±8.1天。对两组创面细胞炎症因子控制时间、创面愈合时间、功能康复时间，治疗组效率高于对照组（P<0.05）。结论 一次性负压VSD引流技术无论在炎症细胞因子控制、创面愈合时间、功能康复更具优势，有助于患者尽快恢复，提升患者的生活质量，值得推荐。

Abstract

Objective To observe the control of inflammatory cytokines and clinical efficacy analysis of treatment with disposable negative pressure drainage technique (Vacuum Sealing Draina VSD) in patients with skin defects, bone defects and infections of extremities.
Methods Ten patients with skin defects, bone defects and infected wounds of the extremities admitted from January 2021 to October 2021 were randomly grouped into a treatment group and a control group, with 5 cases in each group, to compare the effects of treatment with disposable VSD negative pressure drainage technique, conventional drug exchange treatment followed by reoperation, respectively.
Results The inflammatory cytokine control time of 5.0±2.3 days, wound healing time of 18±2.5 days, and functional recovery time of 28±5.5 days for 5 cases treated with disposable VSD negative pressure drainage technique, and the inflammatory cytokine control time of 14.1±3.0 days, wound healing time of 35±4.2 days, and functional recovery time of 53±8.1 days for 5 cases treated with conventional drug exchange. The efficiency of the treatment group was higher than that of the control group (P<0.05) with respect to the time of inflammatory cytokine control, trauma healing, and functional rehabilitation of the trauma cells in both groups.
Conclusion   Disposable negative pressure VSD drainage technique is more advantageous in both inflammatory cytokine control, trauma healing time, and functional recovery, which helps patients recover as soon as possible and improves their quality of life, and is recommended.