The effects of general anesthesia composite epidural anesthesia on oxidative stress and blood glucose levelsin elderly abdominal surgery patients were analyzed
分析全麻复合硬膜外麻醉对老年腹部手术患者氧化应激及血糖水平的影响

摘要

目的 实验将针对老年腹部手术患者实施全麻复合硬膜外麻醉，针对应用后的实际效果做出统计分析，重点关注氧化应激及血糖水平。方法 针对64例老年腹部手术患者进行治疗，样本选自2021年6月至2022年5月就诊的患者，并按照先后顺序分为2组，对照组为全麻，观察组为全麻复合硬膜外麻醉，对比手术麻醉效果和手术情况。结果 从数据可见，观察组患者在氧化应激反应上控制效果较好，在不同时段的应激评分（麻醉诱导前、术后12小时、术后1天）中，观察组短于对照组，具有统计学意义（P＜0.05）。同时，在血糖水平指标上，观察组患者结果较优，在不同时段都较为稳定，与对照组对比差异显著（P＜0.05）。在炎症指标上，重点分析了TNF-α、IL-6、IL-8指标，观察组的情况更优，结果与对照组相比差异显著（P＜0.05）。最后，在患者的精神状态指标对比下，结合MMSE量表分析，可见不同时段中均以观察组患者表现更好，差异显著。结论 采用全麻复合硬膜外麻醉对于老年腹部手术患者的康复治疗效果显著，有助于保持稳定的血糖水平，氧化应激反应降低，炎症指标降低，精神状态得到较好的恢复，值得在继承借鉴中发展。

Abstract

Objective The experiment will be conducted in general anesthesia for elderly abdominal surgery patients, and will make statistical analysis on the actual effect after application, focusing on oxidative stress and blood glucose level.
Methods The 64 elderly patients with abdominal surgery were treated from those treated from June 2021 to May 2022, and were divided into 2 groups. The control group was general anesthesia, the observation group was general anesthesia, and the anesthesia results were compared.
Results According to the data, the patients in the observation group had better results in controlling the oxidative stress response. In the stress scores at different periods (before anesthesia induction, 12 hours, 1 day after surgery and 1 day after surgery), the observation group was shorter than the control group, which was statistically significant (P <0.05). At the same time, in the index of blood glucose level, the patients in the observation group had better results and were relatively stable in different periods, significantly different from the control group (P <0.05). On the inflammation index, the TNF-, IL-6, and IL-8 indicators were mainly analyzed, and the observation group was better, and the results were significantly different compared with the control group (P <0.05). Finally, under the comparison of the patients' mental state indicators and combined with the MMSE scale analysis, it was seen that the patients in the observation group performed better in different periods and were significantly different.
Conclusion   Combined epidural anesthesia is effective for elderly patients undergoing abdominal surgery, helping to maintain a stable blood glucose level, reduce the oxidative stress response, reduce the inflammation index, and better recover their mental state.