Clinical comparative study of different blood purification modes in the treatment of patientswith end-stage renal disease
不同血液净化模式治疗终末期肾病患者的临床对比研究

摘要

目的 分析不同血液净化模式治疗终末期肾病患者的临床效果。方法 将我院2020年1月-2021年12月96例终末期肾病患者，双盲随机法分二组。对照组给予常规血液透析，实验组实施高通量血液透析。比较两组治疗前后甲状旁腺素水平、血磷水平、血尿素氮、血肌酐水平、β-2微球蛋白、炎症应激水平、感染、失衡综合征、皮肤瘙痒等并发症发生率。结果 治疗前两组甲状旁腺素水平、血磷水平、血尿素氮、血肌酐水平、β-2微球蛋白、炎症应激水平比较，P＞0.05，治疗后两组甲状旁腺素水平、血磷水平、血尿素氮、血肌酐水平、β-2微球蛋白、炎症应激水平均显著降低，而其中实验组甲状旁腺素水平、血磷水平、β-2微球蛋白、炎症应激水平显著低于对照组，P＜0.05。而血尿素氮、血肌酐水平和对照组无显著差异，P＞0.05。结论 终末期肾病患者实施高通量血液透析效果确切，可进一步提高透析充分性，更好清除β-2微球蛋白和甲状旁腺素，且可更好控制机体的炎症应激水平，减少并发症发生。

Abstract

Objective To analyze the clinical effect of different blood purification modes in the treatment of patients with end-stage renal disease.
Methods 96 patients with end-stage renal disease in our hospital from January 2020 to December 2021 were divided into two groups by double-blind random method. The control group was given conventional hemodialysis, and the experimental group was given high-flux hemodialysis. The levels of parathyroid hormone, blood phosphorus, blood urea nitrogen, blood creatinine, β-2 microglobulin, inflammatory stress level, infection, imbalance syndrome, skin itching and other complications were compared between the two groups before and after treatment.
Results The levels of parathyroid hormone, blood phosphorus, blood urea nitrogen, serum creatinine, β-2 microglobulin, and inflammatory stress levels were compared between the two groups before treatment, P>0.05. The levels of serum phosphorus, blood urea nitrogen, serum creatinine, β-2 microglobulin, and inflammatory stress were significantly decreased, while the levels of parathyroid hormone, blood phosphate, β-2 microglobulin, and inflammatory stress in the experimental group were significantly reduced. The stimulation level was significantly lower than that of the control group, P<0.05. The blood urea nitrogen and serum creatinine levels were not significantly different from the control group, P>0.05.
Conclusion   The effect of high flux hemodialysis in patients with end-stage renal disease is accurate, which can further improve dialysis adequacy, better clear β-2 microglobulin and parathyroid hormone, and can better control the level of inflammatory stress in the body and reduce complications disease occurs.